I. The MTA was not a placebo-controlled, double-blind clinical trial.
II. The blind classroom raters found no difference in any of the treatment groups, i.e., behavioral interventions were equal to medication interventions.
III. There was no control group of untreated children.
IV. Thirty-two percent of the Medication Management group was already on medication for ADHD at the start of the MTA.
V. The Medication Management group was highly selective (in ways that are not fully described) and probably not typical of children who seek services for "ADHD."
VI. The Medication Management group was relatively small.
VII. The children did not rate themselves improved.
VIII. Most of the subjects were boys.
IX. Drug treatment was continuous for fourteen months; behavioral treatments were stopped earlier.
X. The behavioral treatments were flawed.
XI. Most children suffered from adverse drug reactions (ADRs).
XII. There were no trained observers for ADRS.
XIII. There was no improvement in academic performance.
XIV. There was very little effect on social skills.
XV. All the principal investigators were well-known drug advocates.
XVI. The parents and teachers were exposed to prodrug propaganda.